Abstract

Ali  H. Samir, Ruwaidah S. Saeed and Fadhel S. Matty

DOI : http://dx.doi.org/10.13005/ojc/340131

A series of new phthalimides compounds were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one  with  different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1]_a-i under fusion  conditions. Compounds react with SOCl₂ in the presence of benzene to produce  compounds. Chemical modification of Poly (vinyl alcohol) were obtained by reaction of PVA with compounds using the dimethyl formamide to give compounds. The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra,¹H, C¹³-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the  modified polyvinyl alcohol.

Phthalimide; Polyvinyl Alcohol; Antibacterial and Anticancer Activities

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