ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Reaction of 2-Styryl-Quinazoline-4-Ones With Tetra-Chloro-o-Benzoquinone : Synthesis of -1, 4-Benzodioxins and -4, 5-Ortho Phenylenedioxy-Quinazolone Derivatives of Bactericidal and Fungicidal Activity

Khairy A. M. El-Bayouki1, H. H. Moharram1*, Ali S. El-Sayed2**, H. M. Hosney1 and M. Abdel Hamid3


Abstract:

2-styryl-quinazolones 2 a-j are obtained by condensation of 2-methyl-3 (aryl)-4 (1H) quinazolones 1 with different aldehydes. Thermal reaction of tetrachloro-o-benzoquinone with compounds 2 a-g yielded the "Michael adducts" 1, 4-benzodioxins 3. However, the quinone with compounds 2 h-j, is found to undergo selective cyclo-addition to the 4, 5 C-C double bond of the furyl moiety and thus yielding the ortho-phenylenedioxy-stryrylquinazoIones 4, I. R., u. v., and 1Hnmr spectral determinations for the synthesized products are discussed.

Keywords:

Tetra-Chloro-o-Benzoquinone; Phenylenedioxy-Quinazolone

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