Abstract

Nabeel A. Abdul‐Reda¹and Salwa R. Abdul-Ameer²

DOI : http://dx.doi.org/10.13005/ojc/340144

New derivatives of 8-Chloro theophylline (8-CTh) were synthesized by react 8-CTh and 4-amino acetophenone to prepared 8-(4-acetylphenylamino)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione then the result reacts with some substituted benzaldehyde derivatives to prepared different chalcone compound then the products were allowed to react with thiourea and hydrazine to give Pyrimidine and pyrazoline derivatives respectively. The reaction was monitored by thin‐layer chromatography (TLC) technique. All new compounds were characterized by melting points, elemental analysis, FT‐IR, ¹H, ¹³C and 2D‐NMR spectroscopy. Antimicrobial activity of these derivatives was also determined.

8-Chlorotheophylline; Chalcone; Pyrazoline; Pyrimidine; Antimicrobial

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