Abstract

Ali Kazemi Babaheydari ^1,*, Ehsan Heidari Soureshjani²

DOI : http://dx.doi.org/10.13005/ojc/300270

GABAA receptor is hetero-oligomeric Cl- channel that is elective blocked by the alkaloid bicuculline and modulated by steroids, barbiturates and benzodiazepines. The anticonvulsant activity of Diazepam, Amobarbital and Phenobarbital may be mediated in Section by enhancement of inhibition involving y-aminobutyric acid (GABA). Lavender is one of the maximum effective medicinal plants various therapeutic effects of lavender, so as sedative, spasmolytic, antiviral, and antibacterial activities have been reportage. The molecular docking analyses done indicate the highly and effectively interactions between GABA and the Lavandula angustifolia Mill compounds. Ligand Lavandula angustifolia Mill compounds with GABAA are safer and milder with fewer or no side effects than the drugs currently used in the remedy of lessening high Stress which can be better for the development of new therapeutics to blocked GABAA lessening stress. Results confirm all the Lavandula angustifolia Mill compounds were good binding energy when compared with the binging energies of Diazepam, Amobarbital and Phenobarbital.

Amobarbital; Docking; Diazepam; Lavandula angustifolia Mill; Phenobarbital; GABAA receptor

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