Abstract
Functionalization of carboxylated multiwall nanotubes with dapsone derivatives and study of their antibacterial activities against E.coli and S. aureus
Javad Azizian1*, Malak Hekmati1, Orkideh Ghorban Dadras2
DOI : http://dx.doi.org/10.13005/ojc/300236
Abstract:
Bacteria are becoming resistant to the antibiotics prescribed and therefore new treatments are essential to be developed. Multiwall carbon nanotubes (MWNTs) have interesting antibacterial activities and offering a promising new treatment preventing bacteria from becoming resistant. With this aim, we report for the first time three novel modified carboxylated multiwall carbon nanotubes consisting of MWNT-Dapsone, MWNT-Dapsone-imine and MWNT-Dapsone-imine. Copper complex. The functionalized carboxylated multiwall nanotubes were then characterized by FT-IR, Raman, TEM. Moreover, the antibacterial activity of the MWNT-COOH (A), MWNT-dapsone (B), MWNT-Dapsone-imine (C) MWNT-Dapsoneimine.Copper complex (D) , Dapsone (E(, Dapsone-imine (F), has been investigated against gram-negative Escherichia coli and gram-positive Staphylococcus aureus. These results show that compund F exhibited significant antibacterial activity and have a potential to be used as antibacterial agent.
Keywords:Carboxylated multiwall nanotubes; Dapsone; Functionalization, Characterization; Antibacterial activity
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