Abstract

V. B. Kadu* and A. G. Doshi

2-Acetyl-1 -naphthol on condensation with substituted aniline in presence of concentrated H2SO4 affords 2-(α-substituted phenyl imino) ethyl-1 -naphthol (lla-g). The phenolic schiff bases (Hag) when refluxed n DMSO medium in presence of catalytic amount of I, and in presence of 2.3 drops of concentrated H2SO4 gives 3-methyl-N-phenyl naphtho {2,1 -d] isoxazoline. These compounds are tested against test organism Staphy¬lococcus aureus, Klebsiella pneumoniae, Salmonella typhi, Proteus mirabihs and Bacillus subtiiis. Microbial activity of these compounds were compared with standard drug chloramphenicol.

2-Acetyl-1 -naphthol; H2SO4; Ethyl-1 -naphthol (lla-g), Staphy¬lococcus aureus; Klebsiella pneumoniae; Salmonella typhi

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