Abstract
Influence of Electronic Factors on “Solvent-Free and Catalyst-Free Biginelli Reaction
Tanay Pramanik1*, Tariq Ahmad Wani2 and Ambrish Singh1
DOI : http://dx.doi.org/10.13005/ojc/290354
Abstract:
A series of Biginelli condensation were carried out employing urea, ethyl acetoacetate with a series of different derivatives of benzaldehyde. A green synthetic procedure was followed for performing the Biginelli reactions. The reaction conditions were found to be different for electron rich and electron deficient benzaldehydes. So the electronic effect has shown a significant impact on the reaction condition of the Biginelli condensation.
Keywords:Benzaldehyde;Ethyl Acetoacetate;Urea;Electron donating and Electron withdrawing group;Biginelli reaction
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