Abstract

C. Palanivel, K. Suganya, C. Ramalingan and S. Kabilan

The synthesis of 2,6-diarylpiperidines and the corresponding epimeric alcohols1-3 as well as the synthesis of tetrahydrothiopyran-4-one oxime derivatives4-6 have already been reported1-5. In the present investigation, the effect of temperature and solvent chemical shifts in NMR spectra of the above compounds are presented. For compounds 1-6, the 1H and 13CNMR spectra are recorded in DMSO and tie results are compared with that of the spectra in CDCI3. Coupling constants are calculated for three compounds (4-6). For compounds (1-3)C6D6 is a better solvent in recording the 13CNMR spectra. Dynamic NMR studies shows that all the compounds possess conformational homogenity.

Diarylpiperidines; epimeric; alcohols; tetrahydrothiopyran

[ View HTML Full Text]