Abstract

Mirdula Tyagi

DOI : http://dx.doi.org/10.13005/ojc/300243

'Twelve   new  2- {2"-carbomyl - 5" - [3'-amino-2' – methylmono / dihalosubstituted quinazolin- 4' (3'H) - onomethylene] – 1",3",4" - oxadiazol-2"-yl} -4, 5- dihydroimidazolines were prepared and evaluated for their cardiovascular activity. The most active compound of this series    is    2-{2"-carbomyl-5"-[3'-amino-2'-methyl-6-bromoquinazolin-4'(3'H)-onomethylene]-",3",4"-oxadiazol-2"-yl}-4,5-dihydroimidazolines i.e. compound VIc.

Quinazolinonyl oxadiazoles; acute toxicity studies; hypotensive activity; dogs; synthesis Quinazolinonyloxadiazolyl-imidazolines; acute toxicity studies; hypotensive activity dogs; synthesis.

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