Abstract

Mohsen Keyvanfard^*, Khadijeh Alizad

DOI : http://dx.doi.org/10.13005/ojc/300226

A new sensitive and selective electrochemical sensor was developed for determination of glutathione (GSH) at the surface of carbon paste electrode (CPE) modified with multi-wall carbon nanotubes (MWCNTs) as a sensor and pyrogallol red (PGR) as a mediator. The mechanism of GSH electrochemical behavior at the modified electrode surface was investigated by various electrochemical techniques including chronoamperometry, cyclic voltammetry (CV) and square wave voltammetry (SWV). A linear calibration curve was obtained in the concentration range of GSH of 0.3–500 μmol L^–1, with a limit of detection of 0.19 μmol L^–1. The method was applied to the determination of GSH in urine samples with satisfactory results.

Glutathione; Pyrogallol red; Voltammetry; Multiwall carbon nanotubes.

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