Abstract

M. Mirhossaini^1,2, Mir davood Omrani^3,4 ,  J. Shabani Shayeh⁵, A. Rahimpour⁶, F. Haghiralsadat², V. Mansouri ^3,4*and M. Omidi ⁴

DOI : http://dx.doi.org/10.13005/ojc/330318

In this paper the ultrasensitive electrochemical cytosensor was introduced for prostate cancer cells (Du-145) detection. In this cytosensor Du-145 cells were captured on modified gold electrode by using CD-166 antibody. Also reduced graphene oxide/ gold nanoparticle/ CD-166- horseradish peroxidase (rGO/ AuNP/Ab-HRP) nanoprobes as efficient signal amplifiers was designed for the cancer cells recognition. The presented cytosensor exhibited a good cell-capture ability, wide detection range and low detection limit of 50 cells. This cytosensor has great potential for cancer cell detection in clinical and pathological application.

Electrochemical cytosensor; cancer stem cells; human prostate cancer cells; hybrid nanostructure

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