Abstract

Richa Kothari

DOI : http://dx.doi.org/10.13005/ojc/330340

A series of  copper complexes were prepared from N⁴ – substituted Schiff base ligands having structure [Cu (L)₂] Cl₂ ; where L=  p-methoxybenzylidene ethylenediammine, p-nitrobenzylidene ethylenediammine, p- chloroacetophenone ethylenediammine, p-methoxy acetophenone ethylenediammine, p-nitro acetophenone ethylenediammine. All copper complexes were characterized by various physico-chemical techniques like melting point,TLC, elemental analysis,IR,H¹-NMR,LC-MS,UV-Visible spectra. The magnetic moments and electronic spectral studies suggested distorted octahedral geometry for all the complexes. The monoanionic ethylene diammine  ligands act in a bi dentated mode, binding through azomethine nitrogen  atoms.. The synthesized compounds were screened for their in vitro antibacterial activity using Disc Diffusion method against two strains of gram negative and gram positive bacteria. Tetracycline antibiotic was used as positive control in this test. All the compounds showed significant antibacterial activity in the range of 1-10 mg/ml. Antioxidant activity of the all copper complexes was screened using the DPPH scavenging assay.  In this activity ascorbic acid was used as a positive control .All  complexes exhibited potent antioxidant activity in the range 50-75%. These compounds would be evaluated further for their possible DNA binding, cleavage, antifungal and anti-diabetic activities.

Copper (II) complexes; schiff bases; molecular adducts; pharmacological evaluation Invitro-antibacterial; antioxidant activity

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