Abstract

Sushree Tripathy and Pravin Kumar Kar^*

DOI : http://dx.doi.org/10.13005/ojc/290335

The present study deals with experiments so as to highlight the solute (drug albendazole) – solvent ( water) interactions and related thermodynamic modifications in presence of the hydrotropic agent nicotinamide at different temperatures T (= 298.15 to 313.15)K. Density  and conductivity values of albendazole have been determined in water in (0.2, 0.4, 0.6, 0.8, 1 and 2) mol dm-3 aqueous solutions of nicotinamide at temperatures T(= 298.15, 303.15, 308.15 and 313.15)K, where as solubility was studied at 308.15. A concentration dependent solubility enhancement of albendazole was observed. The solubility data was treated to obtain the concentration dependent solubilization efficiency and the Gibbs free energy of transfer (∆G⁰_tr ) of albendazole from pure water to the solvent systems. From the density values, the limiting partial molar volumes and expansibilities have been calculated. The limiting molar conductance (L0) and Arrhenius activation energy (Es) values have been calculated from the generated conductance values. The thermo physical parameters were discussed in terms of solute solvent interactions.

Albendazole;Nicotinamide;Solubility;Partial molar volumes;Arrhenius activation energy

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