Abstract

Om Prakash^1*, S. A. Iqbal² and G. Jacob³

Present paper deals with the synthesis, spectral characterization and X-ray diffraction study of Zn(II) complex with Pioglitazone a new oral antidiabetic drug.  The conductometric titration using monovariation method indicate that complex is ionic and L₂M type which was further confirmed by Job’s method of continuous variation as modified by Turner and Anderson. Analytical data  agree with the molecular formula of complex viz. [(C₁₉H₁₉N₂O₃S)⁺₂ Zn]2Cl^-. Structure of complex was assigned as tetrahedral, in which ligand molecules lies horizontally joining the central  Zn(II) atom, supported by  IR, ¹H NMR and Mass studies.  X-ray diffraction data also supports the complex formation and symmetry of complex.

Pioglitazone;antidiabetic drug;complex, IR;1H NMR;Mass and X-ray diffraction

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