Abstract
Modeling of IC50 (5-LOX and COX) Activity of Phenol Derivatives Against Leukemia Cells
Sameer Dixit1 and Arun K Sikarwar2
DOI : http://dx.doi.org/10.13005/ojc/330266
Abstract:
Phenols derivatives show different inhibitory selectivities towards 5-LOX and COX and induce cell death in leukemia cell lines. For modeling of activity against Leukemia cell lines K562, HL-60, Raji, MOLT4, 32D, Leukocytes, NIH3T3 etc. of phenol derivatives we used three descriptors Mor20e, Mor04m and RDF045m. 5-LOX and COX Values of Bobels are used to build model for Predicted Activity for 5-LOX and COX.
Keywords:5-LOX; COX; QSAR; QSPR; 3D MoRSE Descriptors; RDF Descriptors; IC50
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