Abstract

Mirdula Tyagi and Archana

DOI : http://dx.doi.org/10.13005/ojc/300248

2-Substitutedphenathiazine was prepared according to the reported method. Ethyl-substitutedphenothiazinoacetates(1a-1b) were prepared by the reaction of ethylchloroacetate in the presence of anhydrous K₂CO_3. 2-amino-5-N¹⁰substituted phenothiazinoacetyl) semicarbazdes/thiosemicarbazides (2a-2d) were synthesized by refluxing compound (1a-1b) with thiosemicarbazide/semicarbazide. Compounds (2a-2d) were then underwent mannich reaction to yield compounds 3a-3d. All the newly synthesized compounds (i.e. 2a-2d and 3a-3d) were evaluated for their anticonvulsant activity. Almost all the compounds have shown promising anticonvulsant activity. Compound 3d was the most potent compound of this series. The most potent compound  was evaluated for its anticonvulsant activity and acute toxicity.

Substitutedphenothiazinoacetylsemicarbazides/thiosemicarbazides, substitutedphenothiazinoacetylsemicarbazido/thiosemicarbazido-2 oxo/thiobarbituric acids, anticonvulsant activity, acute toxicity.

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