Abstract
Synthesis and Evaluation of the Antimicrobial Activity of Dodecyl Trimethyl Ammonium and N-(N, N-Dimethylamino) Propyl Glucosylamine
Théoneste Muhizi
DOI : http://dx.doi.org/10.13005/ojc/300239
Abstract:
In this study Dodecyl trimethyl ammonium sulphate (DTA) was obtained through quaternization reaction between dodecylamine and dimethyl sulfate (yield: 51.5%) while Dimethylamino propyl glucosylamine (DAPGA) was successively synthesized from D-glucose and 3-Dimethylamino propylamine (yield: 93.6%). Both compounds were analyzed through NMR spectroscopy. Evaluation of their biological activity against Salmonella Typhimurium, Staphylococcus aureus and Fusarium oxysporum cubens indicated that at a concentration greater than 0.001 10-4 mole mL-1, DTA significantly inhibited growth of Salmonella Typhimurium and Staphylococcus aureus while DAPGA was not effective. Furthermore, these two compounds showed a pronounced antifungal activity against a toxicogen fungal, Fusarium oxysporum cubens.
Keywords:Dodecyl trimethyl ammonium; Dimethylamino propyl glucosylamine; Salm. Typhimurium; Staph. aureus; F. oxysporum cubens; biocides
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