ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Microwave Synthesis and Antimicrobial Activity of some Copper (II), Cobalt (II), Nickel (II) and Chromium (III) Complexes with Schiff Base 2, 6-Pyridinedi carboxaldehyde-Thiosemicarbazone

1Dr.Mohammed.Fakruddin Ali Ahmed, V. MahammadYunus

DOI : http://dx.doi.org/10.13005/ojc/300114


Abstract:

Some novel Schiff base metal complexes of Cr(III), Co(II), Ni(II) andCu(II) derived from 2, 6-pyridinedicarboxaldehyde-Thiosemicarbazone(PDCTC) was synthesized by conventional as well as microwavemethods. This compound wascharacterized by elemental analysis, FT-IR, Mass, molar conductanceand magneticsusceptibilitymeasurements analyses. Analytical data revealed that all the complexesexhibited 1:1 (metal: ligand) ratio with a coordination number of six.The IR data showed that the ligand coordinates with the metal ions in ahexa-dentate manner. The solid state electricalconductivity of the metal complexes was also measured. Solid state electricalconductivity studies reflected a semi-conducting nature of the complexes. The Schiff base and metal complexes displayed good activity againstthe Gram-positive bacteria Staphylococcus aureus, the Gram-negative bacteriaEscherichia coli and the fungi AspergillusnigerandCandida albicans. The antimicrobialresults also indicated that the metal complexes displayed betterantimicrobial activity as compared to the Schiff bases.

Keywords:

microwave method; hexa-dentate ligands; biologicalactivities.

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