Abstract

Dayadhar Dikshit^*

Currently doctors diagnosis the disease and prescribe medicine on the basis of external symptoms and blood report of the patient. It some times results adverse effect, overdose of medicine. Adverse drug reaction accounted for 2.2 million hospitalizations and over 1,00,000 deaths in USA in 19941. Currently there no simple way to determine whether people will respond well, badly, or not at all to a medication. Pharmacogenomics2 deals with the influence of genetic variation on drug response in patients by correlating gene expression or single nucleotide polymorphism with a drug’s efficacy or toxicity. Therefore it provides a revolutionary pathway to diagnosis the disease and prescribes “Personalized” medicine on the basis patient’s genotype. Genetic variation in drug receptors can have a profound effect on drug efficacy. It has been already reported that variation in sequence of amino acid in DNA directly affects the response of β2 – adrenoreceptor to β2 – agonists3-4. In this paper we discusses polymorphism in DNA and its effect on synthesis of drug metabolizing enzymes in human beans and other organism and it’s use to determining the doze of alternative herbal drugs for patient along with benefits, challenges and various research scope in pharmacogenomics.

Pharmacogenomics; polymorphism; β2-agonists; alternative herbal drug

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