Abstract

Muvvala Subrahmanya Sudhir¹, Pavuluri Madan Mohan² and Ratnakaram Venkata Nadh ^3*

For estimation of the Febuxostat in bulk and pharmaceutical dosage forms, an ultra violet – spectrophotometric method has been developed and validated. The method employed 0.1 N NaOH as solvent. At 275 nm, the linear regression analysis data for the calibration plot showed good linear relationship with correlation coefficient value of 0.998 in the concentration range of 10 – 70 µg/ml. The limit of detection and limit of quantitation were found to be 0.239 µg/ ml and 0.725 µg/ml respectively. The results demonstrated that the pro­cedure is accurate, precise and reproducible (R.S.D. < 2 %).

Febuxostat; Validation; Estimation; UV spectrophotometry; 0.1 N NaOH; Bulk and Pharmaceutical forms

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