Abstract

M.H. Salunke¹, Z.A. Filmwala*, S.B. Dharap¹ and A. D.Kamble¹

In the present study 2-Amino-3-(1H-indol-3-yl)-propionic acid hydrazide (AIPAH) (1) has been prepared by reacting earlier reported compound 2-Amino-3-(1H-indol-3-yl)-propionic acid ethyl ester (AIPAEE) with hydrazine hydrate. Schiff base 3-(1H-Indol-3-yl)-2 [(4-methoxy-bezylidene)-amino]-propionic acid(4-methoxy-benzylidene)-hydrazide(IMBAPAMBH) (2) has been synthesized by reacting (1) with 4-methoxy benzaldehyde and its metal complexes with Fe(III), Co(II), Zn(II), Cd(II), Y(III), and In(III) have been prepared. The ligand and metal complexes were characterized on the basis of elemental analysis, IR, NMR spectral data, molar conductance, magnetic susceptibility measurement, thermal analysis (TGA/DTA). Fe(III), Co(II), Y(III), In (III) complexes possesses octahedral and Zn(II), Cd(II) complexes possesses tetrahedral geometry. In vitro antibacterial and antifungal activities of all compounds were tested.

Synthesis; Schiff base; Fe(III); Co(II); Zn(II); Cd(II); Y(III); and In (III) complexes; Antibacterial and antifungal activities

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