Abstract

Swapneel Sonone*, Harshal Narkhede, Pramod Shirote and Nilofer Naikwade

Chitosan derivative was successively synthesized by initial preparation of acylthiourea reagent using ammonium thiocyanate and making it to react with at primary amino groups of chitosan and then reduced to yield thiolated chitosan. Due to the formation of disulfide bonds with mucus glycoproteins, mucoadhesiveness is augmented. The thiol groups were then quantified using Ellaman’s reagent. The derivatives inherit good swelling property in neutral and alkaline media. The different derivatives containing thiol groups were formulated into tablets using reference drug for evaluation. The thiolated chitosan can guarantee prolonged controlled release of embedded therapeutic ingredients.

Thiolated Chitosan; acyl isothiocyanate; Isopropanolol; Mucoadhesion; Matrix tablet

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