Abstract

J. Valarmathy¹, L. Samuel Joshua², K. L. Senthil kumar² and Amit J

Inflammation of lungs is often related with the tuberculosis and convulsions are associated with the long term therapy of first line anti tubercular agents. Here in this present study an attempt has been made to synthesize the derivatives possesses all three activities. An efficient synthetic method has been established for the synthesis of new 2-Pyrazoline derivative. The synthesized compounds were evaluated for anti tubercular, anticonvulsant and anti-inflammatory activity. The observed increase in activities are attributed to the presence of 2-CH3, 4-NH2 in phenyl ring at 5-position of pyrazoline ring of newly synthesized compounds.

Synthesis; pyrazoline derivatives; tuberculosis

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