Abstract

S. Kumar, A. Kumar, G. Chikara, G. Kumar, P. Kumar, R. kumar, N. Shisodia, B.P. Yadav & Y.P. Garg

N-benzylidene-5-(7-methoxynaphthalene-2-ylamino)methyl)-1,3,4-thiadiazol-2-amine(4a-4e), 3-(5-(7-methoxynaphthalen-2-ylamino)methyl)-1,3,4-thiadiazol-2-yl)-2-phenyl thia-zolidin-4-one (5a-5e) and 3-chloro-1-(5-((7-methoxynaphthalen-2-yl amino)methyl)-1,3,4-thiadiazol-2-yl)-4-phenylazetidin-2-one (6a-6e) have been synthesized in present study. The structures of these newly synthesized compounds were confirmed by their analytical and spectral data. These compounds were also evaluated for their anti-inflammatory, analgesic activities. The compound (6e) was found to exhibit potent anti-inflammatory activity as compared to the standard drugs phenylutazone. The structures of all compounds have been evaluated by elemental and spectral analysis.

Naphthalene derivatives; anti-inflammatory; analgesic activities

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