Abstract
Synthesis, Characterization and Biological Evaluation of 3-Alkyl-5(4-Substituted Benzene Disulphonamido)-1, 2-Benzisoxazoles and its Derivatives
Shivaji Jadhav*, Megha Jadhav, Ayesha Durrani, U.K. Asema, Ayesha Meraj and Hajera Begum
Abstract:
The chlorosulphonic acid treated with 3-alkylbenzisoxazole to give [1A – 9A] which is concentrated with ammonia solution and further acidified with dil. H2SO4 we get sulphonamido derivatives [1B – 9B] which is on substituted with benzene sulphonyl chloride and pH adjusted to 10-11 by 50% NaOH solution to give Disulphonamido derivatives [1C-27°C]. The synthesized compounds characterized by spectral analysis like IR, NMR and Elemental Analysis. The synthesized compound screened by antibacterial activity.
Keywords:Chlorosulphonic acid; substituted Benzisoxazole; NH3; dil. H2SO4, NaOH sulphonamido; antibacterial activity
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