Abstract

F. Rehman and Samya Mairaj

The 2, 4 di-hydroxy butyrophenone Oxime (DHBOX) behaved as mono protic acid and proton was replaced by the metal ion during complex formation & two type of complexes viz 1:1 and 1:2 in the system. The stability constant of DHBOX with bivalent metal ion was calculated. The order of stability constant was in the order Cu(II)>Ni(II)>Mn(II) which is in the agreement with the Irving Williams order. The values of change in free energy (DG), enthalpy (DH) and entropy  (DS) for ligand were calculated at different temperature. The effect of ionic strength and temperature on stability constant were also studied. The antifungal activity and antibacterial activity of different concentration of test compounds were measured by determining the growth of test fungi by dry weight increase method and by agar diffusion method against alternaria alternate & E. coli. The order of antimicrobial effect was observed the following order Cu(II)>Ni(II)>Mn(II).

Thermodynamic and Biological study; DHBOX

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