Abstract

Manoj Kumar and G. R. Verma

New macrocyclic ligand viz., cyclo-(1,2)-dibigunidinylbis{2-hydroxy-w-substituted -benzoyl)}- acetophenone containing substituted benzyolacetophenone and their complexes with Ni(II), Cu(II) & Fe(III) has been synthesized. The ligand and its complexes were investigated by different spectroscopic methods and also evaluated for their antimicrobial activity .The Characterization of these complexes is achieved by elemental analysis, spectral (IR, ¹H NMR, electronic spectra) and thermal analysis. Molar conductance and magnetic moment measurement have also been determined. Microanalytical data clearly shows 1:1 molar ratio of ligand to metal in all complexes. Elemental analysis are in good agreement with the formation of complexes [M (L) (H2O) 2]Cl2 where M= Ni(II), Cu(II) and Fe(III); [L= L1- LV]. On the bases of electronic spectroscopy and magnetic susceptibilities study octahedral geometry assigned for Ni(II) & Fe(III) complexes and distorted octahedral geometry for Cu(II) complexes. The ligand and complexes were evaluated for their antimicrobial activity against different species of bacteria and fungi. Their biopotency has been discussed.

Macrocyclic substituted biguanides; template synthesis and antimicrobial activity

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