Abstract

Priyanka Kedia,Vandana Singh and Daroga Singh*

4-Arylmethylene-2,4-dihydro-2-arylthioanilido-5-methyl-3H-pyrazol-3-ones(2) were prepared by the condensation of 2,4-dihydro-2-arylthioanilido-5-methyl- 3H- pyrazol - 3- ones (1) with aromatic aldehydes in the presence of glacial acetic acid. The synthesized compounds (2) reacted with phenyl thiourea in presence of alcoholic KOH at reflux temperature to give 1-arylthioanilido-3-methyl-4-aryl-6-phenylimino -4,7- dihydro-1, 3- thiazino [5,4-d] pyrazoles (3). The synthesised compounds (3) have been screened for their fungicidal activities against fungi A. fumigatus and C. albicans at different concentrations.

Pyrazolone; thiazono-pyrazoles; Antifungal activity; Thiazono-pyrazoles

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