Abstract

Parthiv K. Chaudhari

The preparation of the 3-amino-4-aryl-4, 5- dihydro-1-N-tolyl pyrazolo [3, 4-d] pyrimidines derivative (V a-m) have been undertaken by the cyclocondensation of aryl aldehyde, urea and 1-N-phenyl-3-amino-5-pyrazolone. The constitution of the product (V a-m) has been characterized by using elemental analyses, IR and PMR spectral data. The products (V a-m) were assayed for their in vitro biological assay like antibacterial activity towards Gram and Gram negative bacterial strain and antifungal activity towards Aspergillus Niger and Candida albicans at different concentration for their MIC values, the biological activities of the synthesized compounds were compared with standard drugs. Some of the obtained compounds showed the interesting antimicrobial activity comparable to standard drugs like amplicillin, chloramphenicol, amoxicillin, ciprofloxacin, norfloxacin and griseofluvin...

pyrazolo [3, 4-d] pyrimidines; antimicrobial activity and antituberculosis activity antimycobacterial activity

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