Abstract

V.  Santhakumari

Spermidine is a naturally occurring polyamine which regulate growth processes in living beings. Using solid phase synthetic strategy spermidine was synthesised. The only purification process involved throughout the synthesis is filtration and washing with suitable solvents.  Spermidine was first synthesised over polystyrene support and then cleaved from matrix photolytically.  The yield and purity of the sample was studied using differently cross linked polystyrene resin with DVB as the cross linking agent. The effect of one photocleavable linker was studied. The synthesis of linker was done by classical organic synthetic procedure.

Solid phase organic synthesis; Spermidine; linkers; photolysis; functionalisation

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