ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis of Acetylated Dihydropyrimidine Analogues Under Solvent free Conditions and their Evaluation as Calcium Channel Blockers

Bhawana Sati1*, Ellamma1, Hemlata Sati2, L.V.G. Nargund3, Somila Khaidem4, Prakash Chandra Bhatt5 and Sarla Saklani6


Abstract:

One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCl2.2H2O affords eight different substituted 3,4-dihydropyrimidine ones/thiones. Further we prepared acetylated 3,4-dihydropyrimidine ones/thiones, on treatment of 3,4-dihydropyrimidine ones/thiones with acetic anhydride using zinc chloride as a catalyst. Calcium channel blocker activity shows that synthesized compounds have moderate activity.

Keywords:

Biginelli reaction; microwave irradiation; acetylated 3;4-dihydropyrimidine ones/thiones; calcium channel blocking activity

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