Abstract

Pinki Sharma and L. K. Tiwary*

Cefuroxime Axetile (CA) is a semi-synthetic broad-spectrum cephalosporin antibiotic for oral administration. The critical micelle concentration (CMC) of this drug determined by spectrophotometric method is found to be 0.2 mM and this value decreases in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). The CMC of CA decreases from 0.2 to 0.12 mM by increasing the concentration of SDS from 0.05 to 5.0 mM. This trend is not regular with CTAB. There is remarkable decrease in CMC of CA from 0.2 to 0.15 mM by increasing concentration of CTAB up to 0.1 mM beyond which it acquires a constant value of 0.14 mM. The effect of CA on micellization of SDS and CTAB has also been investigated in detail in the premicellar region of drug. The CMC of SDS decreases from 7.8 mM to 2.5 mM by increasing the concentration of CA from 0.02 to 0.1 mM. Similar trend has also been observed in case of CTAB where its CMC decreases from 0.86 mM to 0.27 mM within the same concentration range of CA. Effect of temperature on micellization of SDS - CA and CTAB – CA mixed micellar systems has been studied at 303, 313 and 323 K. Physicochemical parameters have been calculated using biphasic model.

Cefuroxime Axetile; Antibiotic agent; Spectrophotometric method

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