Abstract

Sandeep Gupta¹*, S. S. Pancholi² and M. K. Gupta¹

A large variety of 2-substituted benzimidazoles have been found to possess anti-inflammatory, antispasmodic, antihistaminic, antimicrobial, anticancer, cycloxygenase inhibitor, and HIV-1 reverse transcriptase inhibitor activities. 2-Alkyl benzimidazole and 2- aryl benzimidazoles were synthesized with different acids namely acetic acid, o-chlorobenzoic acid, benzoic acid and cinnamic acid. These were further treated with tosyl chloride and benzoyl chloride to get N-substituted benzimidazole derivatives. These N-substituted benzimidazoles were tested for antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Some of the products exhibited interesting activity with known standard drug at same concentration.

Benzimidazoles; antibacterial activity; acid chloride

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