Abstract

Anukul Prasad¹ and B. K. Rai²

Chelates of 1,2-dimethyl-1,4 dihydro-4-oxo-quinazoline (DDOQH) with Co(ll), Ni(ll) and Cu(ll) have been synthesized and characterized on the basis of elemental analysis, IR spectra, magnetic susceptibility, electronic spectra and molar conductance data. On the basis of above observations chelates were proposed to be octahedral geometry with composition {M(DDOQH)2X2} where m= Co(ll) Ni(ll) and Cu(ll), X=Cl-, Br-, I-, NO-3 and ClO4. The ligand DDOQH acts in a bidentate manner and coordination proposed to the metal ion through azomethine N and amino N atom of quinazoline derivatives. The remaining coordination sites are occupied by negative ions such as Cl-, Br-, I-, NO3- and ClO4-. The ligand as well as metal complexes have been tested for antifungal study against two fungi Aspergillus flavus and Penicillium expansum.

DDOQH/Co(ll); Ni(ll) and Cu(ll) schiff base/complexes antifungal activity

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