Abstract
Formulation and Antibacterial Evaluation of Some Novel S-Triazine Based Chalcones and Their Derivatives
Anjani Solankee, Sejal Solankee, and Ghanshyam Patel
Abstract:
Some new chalcones, 2-(4'-chlorophenylamino)-4-(4'-flurophenylamino)-6-[4'-3{3-(substituted phenyl/2-thienyl/2furanyl)-2""-propenon-1""-yl} phenylamino]-s-triazine (6a-e) have been acheived by the reaction between 2-(4'-chlorophenylamino)-4-(4'-flurophenylamino)-6-(4'-acetylphenylamino)-s-triazine (5) and differentt aromatic and heterocycli aldehydes, which on cyclisation with phenyl hydrazine hydrochloride in the presence of alkali give phenyl pyrazolines (7a-e). Chalcones (6a-e) on cyclisation with malononitrile in the presence of ammonium acetate give cyanopyridines (8a-e). The characterization of newly synthesized compounds has been done on the basis of IR, 1H NMR spectral data as well as elemental analysis. The compounds have been evaluated for antibacterial activity against E. coli (MTCC 443), S. paratyphi-B (MTCC 733), S. aureus (MTCC 96) and B. Subtilis (MTCC 441)"
Keywords:Chalcones; pyrazolines; cyanopyridines; spectral data; antibacterial activity
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