ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis of Novel Thiazolidinone and Acetidinone Derivatives and their Anti Microbial Activity

B. D. Mistry*, K. R. Desai and S. M. Intwala


Abstract:

2’-{2-[(2’’’,6’’’-dichlorophenyl) amino] phenyl}-N-(4-oxo-2-substitutedphenyl (1,3-thiazolidin-3-yl))acetamide 4a-j, 2’-{2""-[2’’’, 6’’’-dichlorophenyl) amino]phenyl}-N-(3-chloro-2-oxo-4-substituted phenylazetidinyl) acetamide 5a-j have been synthesized by the reaction of N-((1E)-1-Aza-2-Substituted phenylvinyl)-2’-{2""-[2’’’, 6’’’-Dichloro Phenyl) Amino] Phenyl} Acetamide 3, with thoglycolic acid,, Chloroacetyl chloride and triethyl amine respectively. The compounds have been screened for their antimicrobial activity against different micro-organisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and Mass spectral data."

Keywords:

Thiozolidinone; Azetidinone; Antimicrobial activity

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