ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Syntheses and characterization of some 1, 2, 4-triazole derivatives as biological agents

Ram Janam Singh1* and Dharmendra Kumar Singh2


Abstract:

3-Alkyl -4-amino-4, 5-dihydro-1H-1, 2, 4-triazole-5-one (1) when condensed with di-(3-formyl phenyl)-terephthalate (2) yielded the corresponding novel di-[3-(3-alkyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethinphenyl]-terephthalate (3). All the synthesized compounds were characterized by IR, PMR, Mass spectral data and elemental analyses. All newly synthesized compounds have been assayed for their antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa

Keywords:

4, 5-dihydro-1H-1, 2, 4-triazole-5-one; di-(3-formyl phenyl)-terephthalate; condensation; cyclization; antibacterial activity

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