Abstract

Pinki Sharma and L. K. Tiwary*

Dissolution behaviour of pure cefprozil monohydrate (CM) and cefuroxime axetile (CA) and their marketed tablets have been studied in aqueous as well as micellar media. Dissolution of cefprozil monohydrate is significantly assisted in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). But, SDS and CTAB behave differently in accelerating the dissolution tendency of pure CM and its marketed tablet. Effect of SDS in enhancing the dissolution value of CM tablet is found to higher than that of CTAB whereas this dissolution trend is reversed with pure CM. In case of CA dissolution values are found to be appreciably higher in micellar media as compared to the values in aqueous media. However, SDS shows higher impact in enhancing the dissolution values of CA as compared to that of CTAB for both pure CA and its marketed tablet.

Cefprozil monohydrate; Cefuroxime axetile; Percentage dissolution; Sodium dodecyl surphale; Cetyltrimethylamonomum bromide

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