Abstract

Pinki Sharma and L.K. Tiwary*

Dissolution behaviour of both 5, 5-diphenyl hydantoin sodium commonly known as dilantin sodium (DS) and its corresponding marketed capsule dilantin have been studied in aqueous as well as micellar media. Percentage dissolution of both DS and its marketed capsule are found to be low as expected in aqueous medium due to its very low solubility in water. However, their dissolution tendency is found to be significantly enhanced in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). Impact of SDS and CTAB on the dissolution behaviour of pure DS and on the dilantin capsule are observed to be nearly same.

Dilantin sodium Percentage dissolution; Sodium dodecyl sulphate; Cetyltrimethylammonium bromide

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