Abstract

G.S. Kalwania*, S. Chomal, S. Choudhary, Radhey Shyam and Sunita Kumari

A new environmental benign method for synthesis of phenothiazine derivatives using microwave irradiation has reported. A mixture of o-substituted aromatic amine and p-substituted phenol converted into biphenyl amine derivative using microwave irradiation. Further, thionation of biphenyl amines under same irradiation has provided the title phenothiazine derivatives. The later compounds then oxidized to their 5, 5-dioxide derivatives by 30 % hydrogen peroxide. All the synthesized title compounds have screened for their antimicrobial activity and their structure confirmed by spectral as well as other analytical data.

Phenothiazine; Microwave; Irradiation; Antimicrobial; Spectral

[ View HTML Full Text]