Abstract

B. K. Rai^1*, Sanjay Kumar², Rahul Anand³ and Ashok Pandey⁴

DOI : http://dx.doi.org/10.13005/ojc/290237

A series of coordination compounds have been prepared with tridentate Schiff base ligands, 2 ethyl-[(hydroxy propyl)]- 3, 1 (4H) quinazoline- 4-semicarbazone [EHPQS) and 2-ethyl-[(hydroxy propyl)]- 3, 1 (4H) quinazoline- 4-thiosemicarbozone [EHPQT]. The obtained complexes were characterized by molar mass, elemental analysis, infrared spectra, electronic spectra, magnetic susceptibility molar conductance analysis and spectral studies show that the Schiff base EHPQS/ EHPQT behaves as tridentate chelating agent and coordinated to metal ions via, azomethine nitrogen alcoholic oxygen atom and with either carbonyl or thione sulphur atom of ligand. The electronic spectra and molar susceptibility of the complexes show a distorted octahedral geometry for Cu(II) complexes where as octahedral geometry for Co(II) and NI(II) metal ions. The Schiff base ligand and their metal complexes have been tested for antimicrobial activities against Gram positive bacteria; Staphylococci aureus and Gram negative bacteria Escherichia coli.

EHPQS; EHPQT; Schiff bases; Co(II), Ni(II) and Cu(II); Antimicrobial studies

[ View HTML Full Text]