Abstract

 Mahesh D. Bhanushali^1* and Shiva kumarm Hipparagi²

DOI : http://dx.doi.org/10.13005/ojc/290222

Twelve new 3-(4-substituted benzyl)-5-(4-substituted phenyl)-1-phenyl-4, 5-dihydro-1H-pyrazole derivatives were synthesized by reacting 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one and phenyl hydrazine in ethanol. 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one were synthesized by condensation of substituted phenylacetone and substituted benzaldehyde in NaOH solution. The synthesized compounds were confirmed by spectra data. The compounds were evaluated in-vitro for their antibacterial, antifungal, anti-tubercular activity and in-vivo for their anti-inflammatory activity. Compounds P25, P29, P31 and P32 were found to exhibit good antimicrobial and anti-inflammatory activity.

Pyrazoline; Antibacterial; Antifungal; Anti-tubercular; Anti-inflammatory activity

[ View HTML Full Text]