Abstract

Hanan A. Abdel Fattahattah attah

A series of some newly synthesized aryl sulfonamide derivatives containing pyrazole, oxadiazole, pyrrole and hexahydroquinoline moieties was prepared starting from 4-tosyl aminobenzohydrazide 4. The structure of the newly synthesized compounds were characterized by spectroscopic methods and elemental analysis. Some of the newly synthesized compounds were evaluated in vitro for antimicrobial, analgesic and anti-inflammatory activities. The antimicrobial activity was screened against Gram negative, Gram positive strains and fungi. The result of the antimicrobial activity revealed that most of the tested compounds exhibit antimicrobial and antifungal activities. In addition compound 12 g exhibits antifungal activity against both Aspergillus niger and Candida albicans greater than Nystatin. The analgesic and anti-inflammatory screening showed that compound 11 has higher activity than Celecoxib and Voltarin.

Antimicrobial; Synthesis; Aryl; Sulfonamides

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