Abstract

Ashok Kumar¹*, Sudhir KumarBhati¹,Chatrasal Singh Rajput¹ and Jai Singh²

5-substitutedbenzylideneamino-1,3,4,- thiadiazole-2-thiols (1a-1c), 5-substituted- benzylideneamino-2- thiocarbethoxy- methyl-1,3,4-thiadiazoles (2a-2c), 5- substituted- benzylideneamino-2-(thiosemicarbazidomethyl -thio)- 1,3,4-thidiazoles (3a-3c), 5- substitutedbenzylideneaminno-2-[5'-amino-1',3',4'-thiadiazole-2'-ylthiomethyl]-1,3,4-thiadiazoles ( 4a-4c), 5-substitutedbenzylidene amino-2-[5'-(substituted benzylideneamino-1',3',4'- thiadiazol-2'-yl)-thiomethyl]-1,3,4- thiadiazoles (5a-5l), 5-[4'-oxo-3'-chloro-2'-substitutedphenyl-azetidin-1'-yl]-2-[{5-(4'’’-oxo-3'’’ chloro-2'’’- arylazetidin-1'’’-yl)-1"",3"",4""-thiadiazol -2""-yl}-thiomethyl]-1,3,4-thiadiazoles (6a-6l), have been synthesized in present study. The structures of these newly synthesized compounds are confirmed by their analytical and spectral data. These compounds were also evaluated for their anti-inflammatory, ulcerogenic and analgesic activities. The compound 6J have shown most active anti-inflammatory and analgesic activity with better ulcerogenic activity than phenylbutazone."

Thiadiazoles; azetidinones; anti-inflammatory; ulcerogenic; analgesic activities; toxicity study

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