Abstract

E. Jayachandran¹*, G. M. Sreenivasa², L. V. G. Nargund¹, I. Shanmukha¹ and P. M. Gaikwad²

4-Fluoro-3-chloro aniline treated with potassium thiocyanate in the presence of acetic acid and bromine were converted into 2-amino-6-fluoro-7-chloro (1,3)-benzothiazole which was further treated with hydrazine hydrate in the presence of ethylene glycol results 2-hydrazino-6-fluoro-7-chloro (1,3)-benzothiazole. Which was further treated with various aldehydes in the presence of ethanol and HCl results (substituted benzyl hydrazino)-6-fluoro-7-chloro-(1,3)-benzothiazole, then it was treated with Schiff’s base or azomethine with thioglycolic acid results to get respective thiazolidinones. The above said compound refluxed for two hours with equimolar quantities of various substituted amines in the presence of dimethyl formamide to obtain different respective thiozolidinones derivatives. Some of the compounds have promising anti-inflammatory and anthelmintic activity.

Fluorine; benzothiazoles; thiazolidinones

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