Abstract

K. Dashora*, Swarnlata Saraf and S. Saraf

Two simple, rapid, precise, highly specific and economical Spectrophotometric methods have been developed for the determination of tizanidine hydrochloride in its pharmaceutical dosage forms. Method A is based on the simple Spectrophotometric method with maximum absorbance at 319.5 nm in phosphate buffer 6.8 pH, obeyed linearity over 2-20 μg / ml. Method B is based on the difference Spectrophotometric method. The solutions of standard and pharmaceutical samples were prepared in 0.1 N HCl and 0.1 N NaOH. The absorbances were measured at 319.5 nm for acidic and 239.5 nm for alkaline solution. The difference between the absorbances of acidic and basic solutions was computed. The linearity range was found to be 2-12 μg / ml. Both the methods were validated and applied to the determination of tizanidine hydrochloride in solid dosage forms. It was concluded that the methods developed were accurate, sensitive, economical and precise for the quality control of tizanidine in pharmaceutical preparations.

Tizanidine; buffer; spectrophotometric; analysis

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