Abstract

Sonia Mol Joseph* and James T. Joseph

DOI : http://dx.doi.org/10.13005/ojc/320455

A systematic phytochemical investigation of Andrographis paniculata led to the isolation of a bicyclic diterpenoid lactone andrographolide and a well known plant sterol β-sitosterol from the leaf extract. Andrographolide is one of the major diterpene lactone found in the pant. The structure was elucidated on the basis of spectroscopic analysis like ¹H, ¹³C, ¹³C DEPT, ¹H-¹H COSY, FT-IR, UV-Vis and comparison with the known related compounds. It is very bitter in taste and has been reported to possess significant pharmacological activities like antioxidant, antitumor, anti HIV,cardioprotective and hepatoprotectiveactivities. Recently several studies have been conducted to investigate the pharmacological activities andrographolide proved that it is the one of the main constituent attributed for the therapeutic potential of the plant A. paniculata

Andrographis paniculata; diterpenoid; andrographolide; β-sitosterol.

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