ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
     FacebookTwitterLinkedinMendeley

Abstract

Synthesis and Anticonvulsant Evaluation of Ureas and Thioureas

Mahesh K. Gupta1, Surendra N. Pandeya2, Ram A. Gangwar3 and Ashok Kumar1


Abstract:

A series of aryl ureas and thioureas have been prepared and their anticonvulsant activity evaluated. Phenyl, p-tolyl and p-bromophenyl ureas were found to be most active compounds in the maximal electroshock (MES) test. The thioureas were inactive in the same test. The structures of the synthesized compounds have been confirmed on the basis of their elernental analysis and spectral data.

Keywords:

Ureas; thioureas; Anticonvulsant activity

[ View HTML Full Text]

Back to TOC