Abstract

Mina Mirtaghizadeh and Davood Setamdideh*

DOI : http://dx.doi.org/10.13005/ojc/320329

In this study, we have investigated the selective reduction of aldehydes vs. ketones by NaBH₄/PhCO₂Na/H₂O system under ultrasound irradiation. NaBH₄ (1.25 equivalents) and PhCO₂Na (2 equivalents) is optimized conditions for reduce a variety of aldehydes (1 mmol) in the presence of ketones (1 mmol) to their corresponding alcohols in water as green solvent in high to excellent yields of the product (90-95%). A benzoate-borane complex [PhCO₂-H₃B]Na is possibly the active reductant in the reaction mixture.

NaBH4; Selective Reduction; Aldehydes; PhCO2Na; Ultrasound

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