Abstract

A. B. Patil and T. H. Mhaske

The interaction of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal ions with ampicillin (AMP) and cephalexin (CEP) have been studied by pH-metric technique at 0.1 M (KNO3) ionic strength at 29 ± 0.5 °C in aqueous medium. The data obtained were used to evaluate the values of proton-ligand and metal-ligand stability constants using Irving-Rossotti titration technique. Mixed ligand complex studies of these metal ions using nitrilotriacetic acid (NTA) and iminodiacetic acid (IMDA) as primary ligands and AMP and CEP as secondary ligands also have been carried out pH-metrically at the same conditions.

Transition metal ions; ampicillin; cephalexin; nitrolotriacetic acid and iminodiacetic acid

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